Pub. Date : 2013 Mar
PMID : 23324807
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Whereas midazolam is metabolized by both CYP3A4 and CYP3A5, erythromycin is exclusively oxidized by CYP3A4. | Midazolam | cytochrome P450 family 3 subfamily A member 5 | Homo sapiens |
| 2 | RESULTS: In patients expressing CYP3A5, POR*28 carriers showed 45% lower midazolam metabolic ratios compared with POR*1/*1 patients (P<0.001). | Midazolam | cytochrome P450 family 3 subfamily A member 5 | Homo sapiens |
| 3 | This is in line with a lower CYP3A5 activity toward midazolam for POR*28 carriers. | Midazolam | cytochrome P450 family 3 subfamily A member 5 | Homo sapiens |