Title : Both Kdr and Flt1 play a vital role in hypoxia-induced Src-PLD1-PKCĪ³-cPLA(2) activation and retinal neovascularization.

Pub. Date : 2013 Mar 7

PMID : 23319572






1 Functional Relationships(s)
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1 Hypoxia induced tyrosine phosphorylation of Kdr and Flt1 in mouse retina, and depletion of Kdr or Flt1 blocked hypoxia-induced Src-PLD1-PKCgamma-cPLA2 activation and retinal neovascularization. Tyrosine Rous sarcoma oncogene Mus musculus