Title : Estradiol-17β and its cytochrome P450- and catechol-O-methyltransferase-derived metabolites selectively stimulate production of prostacyclin in uterine artery endothelial cells: role of estrogen receptor-α versus estrogen receptor-β.

Pub. Date : 2013 Feb

PMID : 23319543






1 Functional Relationships(s)
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1 We hypothesized that estradiol-17beta and its metabolites, via ER-alpha or ER-beta, can enhance the prostacyclin/thromboxane ratio through the classic phospholipase A(2), cyclooxygenase-1, and prostacyclin synthase pathway in ovine uterine artery endothelial cells (UAECs) derived from pregnant (P-UAECs) versus nonpregnant (NP-UAECs) ewes. Epoprostenol prostaglandin-endoperoxide synthase 1 Homo sapiens