Pub. Date : 2013 Nov 7
PMID : 23318434
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | On the other hand, Abl interacted with the C-terminal domain of Myc and phosphorylated up to five tyrosine residues in its N-terminus, the principal of which was Y74. | Tyrosine | ABL proto-oncogene 1, non-receptor tyrosine kinase | Homo sapiens |
| 2 | Thus, our data unravel two potential effects of Abl on Myc: first, Abl signaling can indirectly augment acetylation of Myc by p300, and most likely also its transcriptional activity in the nucleus; second, Abl can directly phosphorylate Myc on tyrosine: the resulting form of Myc appears to be cytoplasmic, and its presence correlates with Abl activation in cancer. | Tyrosine | ABL proto-oncogene 1, non-receptor tyrosine kinase | Homo sapiens |
| 3 | Thus, our data unravel two potential effects of Abl on Myc: first, Abl signaling can indirectly augment acetylation of Myc by p300, and most likely also its transcriptional activity in the nucleus; second, Abl can directly phosphorylate Myc on tyrosine: the resulting form of Myc appears to be cytoplasmic, and its presence correlates with Abl activation in cancer. | Tyrosine | ABL proto-oncogene 1, non-receptor tyrosine kinase | Homo sapiens |
| 4 | Thus, our data unravel two potential effects of Abl on Myc: first, Abl signaling can indirectly augment acetylation of Myc by p300, and most likely also its transcriptional activity in the nucleus; second, Abl can directly phosphorylate Myc on tyrosine: the resulting form of Myc appears to be cytoplasmic, and its presence correlates with Abl activation in cancer. | Tyrosine | ABL proto-oncogene 1, non-receptor tyrosine kinase | Homo sapiens |
| 5 | Thus, our data unravel two potential effects of Abl on Myc: first, Abl signaling can indirectly augment acetylation of Myc by p300, and most likely also its transcriptional activity in the nucleus; second, Abl can directly phosphorylate Myc on tyrosine: the resulting form of Myc appears to be cytoplasmic, and its presence correlates with Abl activation in cancer. | Tyrosine | ABL proto-oncogene 1, non-receptor tyrosine kinase | Homo sapiens |