Title : Nicotine induces inhibitor of differentiation-1 in a Src-dependent pathway promoting metastasis and chemoresistance in pancreatic adenocarcinoma.

Pub. Date : 2012 Dec

PMID : 23308043






5 Functional Relationships(s)
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1 Nicotine induces inhibitor of differentiation-1 in a Src-dependent pathway promoting metastasis and chemoresistance in pancreatic adenocarcinoma. Nicotine inhibitor of DNA binding 1, HLH protein Homo sapiens
2 Here, we show that stimulation of pancreatic cancer cells with nicotine concentrations that are within the range of human exposure results in activation of Src kinase, which facilitated the induction of the inhibitor of differentiation-1 (Id1) transcription factor. Nicotine inhibitor of DNA binding 1, HLH protein Homo sapiens
3 Here, we show that stimulation of pancreatic cancer cells with nicotine concentrations that are within the range of human exposure results in activation of Src kinase, which facilitated the induction of the inhibitor of differentiation-1 (Id1) transcription factor. Nicotine inhibitor of DNA binding 1, HLH protein Homo sapiens
4 Depletion of Id1 prevented nicotine-mediated induction of proliferation and invasion of pancreatic cancer cells, indicating that it is a major mediator of nicotine function. Nicotine inhibitor of DNA binding 1, HLH protein Homo sapiens
5 Depletion of Id1 prevented nicotine-mediated induction of proliferation and invasion of pancreatic cancer cells, indicating that it is a major mediator of nicotine function. Nicotine inhibitor of DNA binding 1, HLH protein Homo sapiens