Title : Inhibitory effect of nicardipine on rotenone‑induced apoptosis in SH‑SY5Y human neuroblastoma cells.

Pub. Date : 2013 Mar

PMID : 23291720






3 Functional Relationships(s)
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1 Rotenone increased phosphorylation of c-Jun NH2-terminal kinase (JNK) and p38 MAPK, whereas nicardipine blocked these increases. Rotenone mitogen-activated protein kinase 8 Homo sapiens
2 Rotenone increased phosphorylation of c-Jun NH2-terminal kinase (JNK) and p38 MAPK, whereas nicardipine blocked these increases. Rotenone mitogen-activated protein kinase 8 Homo sapiens
3 These results indicate that nicardipine exerts a protective effect against rotenone-induced apoptosis in SH-SY5Y cells, inhibiting phosphorylation of JNK and p38 MAPK and activation of CASPs. Rotenone mitogen-activated protein kinase 8 Homo sapiens