Title : The clinically-tested S1P receptor agonists, FTY720 and BAF312, demonstrate subtype-specific bradycardia (S1P₁) and hypertension (S1P₃) in rat.

Pub. Date : 2012

PMID : 23285242






1 Functional Relationships(s)
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1 infusion of FTY720 (0.1, 0.3, 1.0 mg/kg/20 min) or BAF312 (0.5, 1.5, 5.0 mg/kg/20 min) elicited acute bradycardia in anesthetized rats demonstrating an S1P1 mediated mechanism-of-action. Fingolimod Hydrochloride sphingosine-1-phosphate receptor 1 Rattus norvegicus