Pub. Date : 2013 Jan 15
PMID : 23277563
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | In a Src-inducible model of cellular transformation, metformin inhibits the earliest known step in the process, activation of the inflammatory transcription factor NF-kappaB. | Metformin | nuclear factor kappa B subunit 1 | Homo sapiens |
| 2 | The antitransformation effect of metformin can be bypassed by overexpression of Lin28B or IL1beta, downstream targets of NF-kappaB. | Metformin | nuclear factor kappa B subunit 1 | Homo sapiens |
| 3 | Metformin preferentially inhibits nuclear translocation of NF-kappaB and phosphorylation of STAT3 in cancer stem cells compared with non-stem cancer cells in the same population. | Metformin | nuclear factor kappa B subunit 1 | Homo sapiens |