Title : Metformin inhibits the inflammatory response associated with cellular transformation and cancer stem cell growth.

Pub. Date : 2013 Jan 15

PMID : 23277563






3 Functional Relationships(s)
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1 In a Src-inducible model of cellular transformation, metformin inhibits the earliest known step in the process, activation of the inflammatory transcription factor NF-kappaB. Metformin nuclear factor kappa B subunit 1 Homo sapiens
2 The antitransformation effect of metformin can be bypassed by overexpression of Lin28B or IL1beta, downstream targets of NF-kappaB. Metformin nuclear factor kappa B subunit 1 Homo sapiens
3 Metformin preferentially inhibits nuclear translocation of NF-kappaB and phosphorylation of STAT3 in cancer stem cells compared with non-stem cancer cells in the same population. Metformin nuclear factor kappa B subunit 1 Homo sapiens