Title : Distinct phosphotyrosine-dependent functions of the ShcA adaptor protein are required for transforming growth factor β (TGFβ)-induced breast cancer cell migration, invasion, and metastasis.

Pub. Date : 2013 Feb 15

PMID : 23277357






1 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 We demonstrate that Grb2 is required specifically downstream of Tyr(313), whereas the Tyr(239)/Tyr(240) phosphorylation sites require the Crk adaptor proteins to augment TGFbeta-induced migration and invasion. Tyrosine growth factor receptor bound protein 2 Homo sapiens