Pub. Date : 2012 Dec
PMID : 23276558
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Effects of curcumin and demethoxycurcumin on amyloid-beta precursor and tau proteins through the internal ribosome entry sites: a potential therapeutic for Alzheimer"s disease. | Curcumin | microtubule associated protein tau | Homo sapiens |
| 2 | OBJECTIVE: This study aims to determine the effects of curcumin and demethoxycurcumin on the internal ribosome entry site of the amyloid-beta precursor protein (APP) and tau protein through a bi-cistronic reporter assay for screening of anti-Alzheimer"s disease agents. | Curcumin | microtubule associated protein tau | Homo sapiens |
| 3 | RESULTS: The bi-cistronic reporter assay revealed that curcumin was more effective than demethoxycurcumin, a structural analog of curcumin, in inhibiting both APP and tau IRES-dependent translation initiation. | Curcumin | microtubule associated protein tau | Homo sapiens |
| 4 | RESULTS: The bi-cistronic reporter assay revealed that curcumin was more effective than demethoxycurcumin, a structural analog of curcumin, in inhibiting both APP and tau IRES-dependent translation initiation. | Curcumin | microtubule associated protein tau | Homo sapiens |
| 5 | This result was further confirmed by Western blot analysis for the expression of APP C-terminal protein, human tau-1, pS(262) and pS(396) suggesting that curcumin may play a role in AD pathology alleviation through the inhibition of the APP and tau IRES-mediated translation mechanism. | Curcumin | microtubule associated protein tau | Homo sapiens |