Title : Synthesis and biological evaluation of analogues of the kinase inhibitor nilotinib as Abl and Kit inhibitors.

Pub. Date : 2013 Feb 1

PMID : 23273517






2 Functional Relationships(s)
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1 Synthesis and biological evaluation of analogues of the kinase inhibitor nilotinib as Abl and Kit inhibitors. nilotinib ABL proto-oncogene 1, non-receptor tyrosine kinase Homo sapiens
2 Docking of nilotinib and of analogues 2a-c to the binding pocket of Abl and of Kit showed that the lack of shape complementarity in Kit is compensated by the stabilizing effect from its juxtamembrane region. nilotinib ABL proto-oncogene 1, non-receptor tyrosine kinase Homo sapiens