Pub. Date : 2013 Sep
PMID : 23272906
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Targeting mTOR: evaluating the therapeutic potential of resveratrol for cancer treatment. | Resveratrol | mechanistic target of rapamycin kinase | Homo sapiens |
| 2 | Over the past few years, numerous studies have suggested that suppressing the activity of mammalian target of rapamycin (mTOR), a critical regulator of cell metabolism, growth, and proliferation, may provide a key mechanism underlying the anticarcinogenic properties of resveratrol. | Resveratrol | mechanistic target of rapamycin kinase | Homo sapiens |
| 3 | Over the past few years, numerous studies have suggested that suppressing the activity of mammalian target of rapamycin (mTOR), a critical regulator of cell metabolism, growth, and proliferation, may provide a key mechanism underlying the anticarcinogenic properties of resveratrol. | Resveratrol | mechanistic target of rapamycin kinase | Homo sapiens |
| 4 | It has been found that resveratrol targets multiple components of the phosphatidylinositol 3- kinase(PI3K)/Akt and mTOR signaling pathways, including PI3K, Akt, PTEN, and DEPTOR, suggesting that this natural compound and its derivatives may offer a promising new cancer treatment. | Resveratrol | mechanistic target of rapamycin kinase | Homo sapiens |
| 5 | In the current review, we discuss recent findings on the molecular mechanisms regulating mTOR signaling and the therapeutic potential of resveratrol for cancer treatment by targeting mTOR. | Resveratrol | mechanistic target of rapamycin kinase | Homo sapiens |