Pub. Date : 2012 Dec
PMID : 23271287
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The elevated ROS was strongly associated with the activation of JNK and ERK1/2 signal pathways after MPP(+) exposure, since the pretreatment of NAC significantly reduced the upregulation of p-JNK and p-ERK1/2. | Reactive Oxygen Species | mitogen-activated protein kinase 8 | Rattus norvegicus |
| 2 | The elevated ROS was strongly associated with the activation of JNK and ERK1/2 signal pathways after MPP(+) exposure, since the pretreatment of NAC significantly reduced the upregulation of p-JNK and p-ERK1/2. | Reactive Oxygen Species | mitogen-activated protein kinase 8 | Rattus norvegicus |
| 3 | In conclusion, our results suggest that JNK and ERK1/2 signal pathways, which are activated via ROS, play a crucial role in neuronal apoptosis induced by oxidative stress. | Reactive Oxygen Species | mitogen-activated protein kinase 8 | Rattus norvegicus |