Title : Inhibition pattern of sulfamide-related compounds in binding to carbonic anhydrase isoforms I, II, VII, XII and XIV.

Pub. Date : 2013 Mar 15

PMID : 23266178






2 Functional Relationships(s)
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1 The biological assays showed a broad range of inhibitory activity, and interesting results were found for several compounds in terms of activity (Ki <1mum) and selectivity: some aromatic sulfamides are active against CA I, CA II and/or CA VII; while they are less active in CA XII and CA XIV. sulfamides carbonic anhydrase 7 Homo sapiens
2 On the other hand, bulky sulfamides are selective to CA VII. sulfamides carbonic anhydrase 7 Homo sapiens