Title : PKCδ Regulates Translation Initiation through PKR and eIF2α in Response to Retinoic Acid in Acute Myeloid Leukemia Cells.

Pub. Date : 2012

PMID : 23259068






1 Functional Relationships(s)
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1 ATRA and ATO induce Ser-51 phosphorylation (inactivation) of eIF2alpha, through the induction of protein kinase C delta (PKCdelta) and PKR, but not other eIF2alpha kinases, such as GCN2 and PERK in APL (NB4) and AML cells (HL60, U937, and THP-1). Arsenic Trioxide eukaryotic translation initiation factor 2 alpha kinase 3 Homo sapiens