Title : Piceatannol inhibits MMP-9-dependent invasion of tumor necrosis factor-α-stimulated DU145 cells by suppressing the Akt-mediated nuclear factor-κB pathway.

Pub. Date : 2013 Jan

PMID : 23255946






3 Functional Relationships(s)
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1 Piceatannol inhibits MMP-9-dependent invasion of tumor necrosis factor-alpha-stimulated DU145 cells by suppressing the Akt-mediated nuclear factor-kappaB pathway. 3,3',4,5'-tetrahydroxystilbene AKT serine/threonine kinase 1 Homo sapiens
2 Furthermore, TNF-alpha-induced Akt phosphorylation was significantly downregulated in the presence of piceatannol. 3,3',4,5'-tetrahydroxystilbene AKT serine/threonine kinase 1 Homo sapiens
3 Overall, these data suggest that piceatannol inhibits TNF-alpha-induced invasion by suppression of MMP-9 activation via the Akt-mediated NF-kappaB pathway in DU145 prostate cancer cells. 3,3',4,5'-tetrahydroxystilbene AKT serine/threonine kinase 1 Homo sapiens