Pub. Date : 2013 Jan
PMID : 23255946
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Piceatannol inhibits MMP-9-dependent invasion of tumor necrosis factor-alpha-stimulated DU145 cells by suppressing the Akt-mediated nuclear factor-kappaB pathway. | 3,3',4,5'-tetrahydroxystilbene | matrix metallopeptidase 9 | Homo sapiens |
| 2 | The aim of the current study was to investigate the effects of piceatannol on the expression of matrix metalloproteinase-9 (MMP-9) in DU145 human prostate cancer cells. | 3,3',4,5'-tetrahydroxystilbene | matrix metallopeptidase 9 | Homo sapiens |
| 3 | The aim of the current study was to investigate the effects of piceatannol on the expression of matrix metalloproteinase-9 (MMP-9) in DU145 human prostate cancer cells. | 3,3',4,5'-tetrahydroxystilbene | matrix metallopeptidase 9 | Homo sapiens |
| 4 | However, treatment with piceatannol reversed TNF-alpha- and MMP-9-induced gelatin zymography and its gene expression. | 3,3',4,5'-tetrahydroxystilbene | matrix metallopeptidase 9 | Homo sapiens |
| 5 | Therefore, whether piceatannol acts on NF-kappaB to regulate MMP-9 gene expression was analyzed. | 3,3',4,5'-tetrahydroxystilbene | matrix metallopeptidase 9 | Homo sapiens |
| 6 | The results revealed that piceatannol attenuates MMP-9 gene expression via the suppression of NF-kappaB activity. | 3,3',4,5'-tetrahydroxystilbene | matrix metallopeptidase 9 | Homo sapiens |
| 7 | Overall, these data suggest that piceatannol inhibits TNF-alpha-induced invasion by suppression of MMP-9 activation via the Akt-mediated NF-kappaB pathway in DU145 prostate cancer cells. | 3,3',4,5'-tetrahydroxystilbene | matrix metallopeptidase 9 | Homo sapiens |