Pub. Date : 2013 Feb
PMID : 23249875
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Contribution of CYP2B6 alleles in explaining extreme (S)-methadone plasma levels: a CYP2B6 gene resequencing study. | Methadone | cytochrome P450 family 2 subfamily B member 6 | Homo sapiens |
| 2 | BACKGROUND: (S)-Methadone, metabolized mainly by CYP2B6, shows a wide interindividual variability in its pharmacokinetics and pharmacodynamics. | Methadone | cytochrome P450 family 2 subfamily B member 6 | Homo sapiens |
| 3 | METHODS: Resequencing of the CYP2B6 gene was performed in 12 and 35 selected individuals with high (S)-methadone plasma exposure and low (S)-methadone plasma exposure, respectively, from a previously described cohort of 276 patients undergoing methadone maintenance treatment. | Methadone | cytochrome P450 family 2 subfamily B member 6 | Homo sapiens |
| 4 | METHODS: Resequencing of the CYP2B6 gene was performed in 12 and 35 selected individuals with high (S)-methadone plasma exposure and low (S)-methadone plasma exposure, respectively, from a previously described cohort of 276 patients undergoing methadone maintenance treatment. | Methadone | cytochrome P450 family 2 subfamily B member 6 | Homo sapiens |
| 5 | METHODS: Resequencing of the CYP2B6 gene was performed in 12 and 35 selected individuals with high (S)-methadone plasma exposure and low (S)-methadone plasma exposure, respectively, from a previously described cohort of 276 patients undergoing methadone maintenance treatment. | Methadone | cytochrome P450 family 2 subfamily B member 6 | Homo sapiens |
| 6 | CONCLUSION: Known genetic polymorphisms in CYP2B6 contribute toward explaining extreme (S)-methadone plasma levels observed in a cohort of patients following methadone maintenance treatment. | Methadone | cytochrome P450 family 2 subfamily B member 6 | Homo sapiens |
| 7 | CONCLUSION: Known genetic polymorphisms in CYP2B6 contribute toward explaining extreme (S)-methadone plasma levels observed in a cohort of patients following methadone maintenance treatment. | Methadone | cytochrome P450 family 2 subfamily B member 6 | Homo sapiens |