Pub. Date : 2013 Mar
PMID : 23249147
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Protective effect of quercetin on lead-induced oxidative stress and endoplasmic reticulum stress in rat liver via the IRE1/JNK and PI3K/Akt pathway. | Quercetin | mitogen-activated protein kinase 8 | Rattus norvegicus |
| 2 | In the examined unfolded protein response (UPR) pathways, quercetin markedly inhibited the Pb-induced increase of the phosphorylated inositol-requiring enzyme 1 (IRE1) and c-jun N-terminal kinase (JNK) in rat liver. | Quercetin | mitogen-activated protein kinase 8 | Rattus norvegicus |
| 3 | In the examined unfolded protein response (UPR) pathways, quercetin markedly inhibited the Pb-induced increase of the phosphorylated inositol-requiring enzyme 1 (IRE1) and c-jun N-terminal kinase (JNK) in rat liver. | Quercetin | mitogen-activated protein kinase 8 | Rattus norvegicus |
| 4 | Taken together, these results suggested that the inhibition of Pb-induced ER stress by quercetin is due at least in part to its anti-oxidant stress activity and its ability to modulate the PI3K/Akt and IRE1/JNK signaling pathway. | Quercetin | mitogen-activated protein kinase 8 | Rattus norvegicus |