Title : Protective effect of quercetin on lead-induced oxidative stress and endoplasmic reticulum stress in rat liver via the IRE1/JNK and PI3K/Akt pathway.

Pub. Date : 2013 Mar

PMID : 23249147






3 Functional Relationships(s)
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1 Protective effect of quercetin on lead-induced oxidative stress and endoplasmic reticulum stress in rat liver via the IRE1/JNK and PI3K/Akt pathway. Quercetin AKT serine/threonine kinase 1 Rattus norvegicus
2 Additionally, quercetin dramatically increased Phosphoinositide-3-kinase (PI3K) and phosphorylated protein kinase B (PKB/Akt) levels in liver rats. Quercetin AKT serine/threonine kinase 1 Rattus norvegicus
3 Taken together, these results suggested that the inhibition of Pb-induced ER stress by quercetin is due at least in part to its anti-oxidant stress activity and its ability to modulate the PI3K/Akt and IRE1/JNK signaling pathway. Quercetin AKT serine/threonine kinase 1 Rattus norvegicus