Pub. Date : 2013 Feb 15
PMID : 23243220
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Influence of human OATP1B1, OATP1B3, and OATP1A2 on the pharmacokinetics of methotrexate and paclitaxel in humanized transgenic mice. | Methotrexate | solute carrier organic anion transporter family member 1B1 | Homo sapiens |
| 2 | We aimed to determine the influence of the individual human OATP1B1, OATP1B3, and OATP1A2 transporters on the in vivo disposition of the anticancer drugs methotrexate and paclitaxel by using liver-specific humanized OATP1A/1B transgenic mice. | Methotrexate | solute carrier organic anion transporter family member 1B1 | Homo sapiens |
| 3 | RESULTS: Humanized OATP1B1, OATP1B3, and OATP1A2 transgenic mice all showed partial or complete rescue of increased plasma bilirubin levels, but also of the increased plasma levels and decreased liver and small intestinal accumulation of methotrexate observed in Slco1a/1b(-/-) mice. | Methotrexate | solute carrier organic anion transporter family member 1B1 | Homo sapiens |