Title : Cis-guggulsterone inhibits the IKK/NF-κB pathway, whereas trans-guggulsterone inhibits MAPK/AP-1 in MCF‑7 breast cancer cells: guggulsterone regulates MMP‑9 expression in an isomer-specific manner.

Pub. Date : 2013 Feb

PMID : 23242121






3 Functional Relationships(s)
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1 Cis-guggulsterone inhibits the IKK/NF-kappaB pathway, whereas trans-guggulsterone inhibits MAPK/AP-1 in MCF-7 breast cancer cells: guggulsterone regulates MMP-9 expression in an isomer-specific manner. pregna-4,17-diene-3,16-dione nuclear factor kappa B subunit 1 Homo sapiens
2 Cis-guggulsterone inhibited TPA-induced MMP expression by blocking IkappaB kinase (IKK)/NF-kappaB signaling, whereas trans-guggulsterone blocked mitogen-activated protein kinase (MAPK)/AP-1 signaling. pregna-4,17-diene-3,16-dione nuclear factor kappa B subunit 1 Homo sapiens
3 These results suggest that guggulsterone isomers downregulate MMP-9 expression and tumor cell invasion through the isomer-specific suppression of IKK/NF-kappaB and MAPK/AP-1 activation. pregna-4,17-diene-3,16-dione nuclear factor kappa B subunit 1 Homo sapiens