Pub. Date : 2013 Feb
PMID : 23239810
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Crizotinib-resistant NPM-ALK mutants confer differential sensitivity to unrelated Alk inhibitors. | Crizotinib | nucleophosmin 1 | Homo sapiens |
| 2 | Here, we focused our attention on the anaplastic large cell lymphoma (ALCL), where the oncogenic fusion protein NPM-ALK, responsible for 70% to 80% of cases, represents an ideal crizotinib target. | Crizotinib | nucleophosmin 1 | Homo sapiens |
| 3 | We selected and characterized 2 human NPM-ALK+ ALCL cell lines, KARPAS-299 and SUP-M2, able to survive and proliferate at different crizotinib concentrations. | Crizotinib | nucleophosmin 1 | Homo sapiens |
| 4 | These mutations also conferred resistance to crizotinib in Ba/F3 cells expressing human NPM-ALK. | Crizotinib | nucleophosmin 1 | Homo sapiens |