Pub. Date : 2013 Feb
PMID : 23218026
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Imatinib and Nilotinib inhibit Bcr-Abl-induced ROS through targeted degradation of the NADPH oxidase subunit p22phox. | Reactive Oxygen Species | ABL proto-oncogene 1, non-receptor tyrosine kinase | Homo sapiens |
| 2 | Constitutive expression of the Bcr-Abl kinase in Chronic Myelogenous Leukaemia (CML) is known to produce elevated levels of Reactive Oxygen Species (ROS) which can enhance cell survival as well as generate genomic instability. | Reactive Oxygen Species | ABL proto-oncogene 1, non-receptor tyrosine kinase | Homo sapiens |
| 3 | Constitutive expression of the Bcr-Abl kinase in Chronic Myelogenous Leukaemia (CML) is known to produce elevated levels of Reactive Oxygen Species (ROS) which can enhance cell survival as well as generate genomic instability. | Reactive Oxygen Species | ABL proto-oncogene 1, non-receptor tyrosine kinase | Homo sapiens |
| 4 | Our laboratory has previously demonstrated that NADPH oxidase (Nox) activity contributes to intracellular-ROS levels in Bcr-Abl-positive cells, while inducing increased pro-survival signalling through the PI3K/Akt pathway. | Reactive Oxygen Species | ABL proto-oncogene 1, non-receptor tyrosine kinase | Homo sapiens |
| 5 | In this study, using the K562 CML cell line we showed that inhibition of Bcr-Abl signalling, by either Imatinib or Nilotinib, led to a significant reduction in ROS levels which was concurrent with the GSK-3beta dependent, post-translational down-regulation of the small membrane-bound protein p22phox, an essential component of the Nox complex. | Reactive Oxygen Species | ABL proto-oncogene 1, non-receptor tyrosine kinase | Homo sapiens |
| 6 | Taken together we believe our results provide a possible link between Bcr-Abl signalling and ROS production through Nox activity and demonstrate a novel mechanism of action associated with Imatinib and Nilotinib treatment in CML. | Reactive Oxygen Species | ABL proto-oncogene 1, non-receptor tyrosine kinase | Homo sapiens |