Title : Gα(h)/transglutaminase-2 activity is required for maximal activation of adenylylcyclase 8 in human and rat glioma cells.

Pub. Date : 2013 Mar

PMID : 23200849






3 Functional Relationships(s)
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1 In rat C6 glioma cells that express endogenous Galpha(h)/TG2, cAMP accumulation induced by isoproterenol or forskolin was significantly inhibited by overexpression of Galpha(h)/TG2-C277V, a dominant-negative mutant that lacks transglutaminase activity, but was not inhibited by the Galpha(h)/TG2-S171E mutant that cannot bind GTP/GDP. Guanosine Diphosphate succinate-CoA ligase GDP/ADP-forming subunit alpha Homo sapiens
2 In rat C6 glioma cells that express endogenous Galpha(h)/TG2, cAMP accumulation induced by isoproterenol or forskolin was significantly inhibited by overexpression of Galpha(h)/TG2-C277V, a dominant-negative mutant that lacks transglutaminase activity, but was not inhibited by the Galpha(h)/TG2-S171E mutant that cannot bind GTP/GDP. Guanosine Diphosphate succinate-CoA ligase GDP/ADP-forming subunit alpha Homo sapiens
3 In rat C6 glioma cells that express endogenous Galpha(h)/TG2, cAMP accumulation induced by isoproterenol or forskolin was significantly inhibited by overexpression of Galpha(h)/TG2-C277V, a dominant-negative mutant that lacks transglutaminase activity, but was not inhibited by the Galpha(h)/TG2-S171E mutant that cannot bind GTP/GDP. Guanosine Diphosphate succinate-CoA ligase GDP/ADP-forming subunit alpha Homo sapiens