Pub. Date : 2013 Mar
PMID : 23195829
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | We found that in the presence of stable cGMP analogs RhoGEF17 associates with and is phosphorylated by co-expressed cGKIalpha at distinct phosphorylation sites leading to a cooperative activation of RhoA, the Rho dependent kinases (ROCK) and serum response factor-induced gene transcription. | Cyclic GMP | ras homolog family member A | Homo sapiens |
| 2 | Together with the ROCK-enforced activation of RhoGEF17 by cGMP/cGKIalpha, this might explain why expression of RhoGEF17 switches the inhibitory effect of cGMP/cGKIalpha on serum-induced RhoA activation into a stimulatory one. | Cyclic GMP | ras homolog family member A | Homo sapiens |
| 3 | Together with the ROCK-enforced activation of RhoGEF17 by cGMP/cGKIalpha, this might explain why expression of RhoGEF17 switches the inhibitory effect of cGMP/cGKIalpha on serum-induced RhoA activation into a stimulatory one. | Cyclic GMP | ras homolog family member A | Homo sapiens |
| 4 | We conclude that RhoGEF17, depending on its expression profile and level, might drastically alter the effect of cGMP/cGK involving signaling pathways on RhoA-activated downstream effectors. | Cyclic GMP | ras homolog family member A | Homo sapiens |