Title : ABT-737 promotes tBid mitochondrial accumulation to enhance TRAIL-induced apoptosis in glioblastoma cells.

Pub. Date : 2012 Nov 29

PMID : 23190604






3 Functional Relationships(s)
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1 Interestingly, the concerted action of ABT-737 and TRAIL to trigger the accumulation of truncated Bid (tBid) at mitochondrial membranes is identified as a key underlying mechanism. tBID BH3 interacting domain death agonist Homo sapiens
2 ABT-737 and TRAIL cooperate to cleave BH3-interacting domain death agonist (Bid) into its active fragment tBid, leading to increased accumulation of tBid at mitochondrial membranes. tBID BH3 interacting domain death agonist Homo sapiens
3 ABT-737 and TRAIL cooperate to cleave BH3-interacting domain death agonist (Bid) into its active fragment tBid, leading to increased accumulation of tBid at mitochondrial membranes. tBID BH3 interacting domain death agonist Homo sapiens