Pub. Date : 2012 Nov
PMID : 23187004
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Synergistic inhibition of mesothelioma cell growth by the combination of clofarabine and resveratrol involves Nrf2 downregulation. | Clofarabine | NFE2 like bZIP transcription factor 2 | Homo sapiens |
| 2 | To further characterize its biological significance, the response of Nrf2, a transcription factor that regulates ARE-containing genes, on the synergistic cytotoxic effect of clofarabine and resveratrol was investigated in mesothelioma cells. | Clofarabine | NFE2 like bZIP transcription factor 2 | Homo sapiens |
| 3 | Altogether, these results suggest that the synergistic cytotoxic effect of clofarabine and resveratrol was mediated, at least in part, through suppression of Nrf2 signaling. | Clofarabine | NFE2 like bZIP transcription factor 2 | Homo sapiens |