Title : N-acetylcysteine attenuates renal alterations induced by senescence in the rat.

Pub. Date : 2013 Feb

PMID : 23183129






2 Functional Relationships(s)
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1 In addition, NAC-treated rats showed upregulated expression of NKCC2, AQP2, and UT-A1; elevated Klotho protein expression, low p53 expression, and few ED-1 positive cells. Acetylcysteine aquaporin 2 Rattus norvegicus
2 In conclusion, we attribute these beneficial effects of NAC (the significant improvements in inulin clearance and in the expression of NKCC2, AQP2, and UT-A1) to its ability to decrease oxidative stress, inhibit p53 expression, minimize kidney inflammation, and stimulate Klotho expression. Acetylcysteine aquaporin 2 Rattus norvegicus