Title : ERK1/2-dependent phosphorylation and nuclear translocation of PKM2 promotes the Warburg effect.

Pub. Date : 2012 Dec

PMID : 23178880






2 Functional Relationships(s)
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1 Here we demonstrate that EGFR-activated ERK2 binds directly to PKM2 Ile 429/Leu 431 through the ERK2 docking groove and phosphorylates PKM2 at Ser 37, but does not phosphorylate PKM1. Serine epidermal growth factor receptor Homo sapiens
2 In addition, levels of PKM2 Ser 37 phosphorylation correlate with EGFR and ERK1/2 activity in human glioblastoma specimens. Serine epidermal growth factor receptor Homo sapiens