Pub. Date : 2013 Jan 4
PMID : 23178716
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | We now report that As2O3 increases phosphorylation of EGFR/p66ShcA and EGFR degradation. | Arsenic Trioxide | epidermal growth factor receptor | Homo sapiens |
| 2 | We now report that As2O3 increases phosphorylation of EGFR/p66ShcA and EGFR degradation. | Arsenic Trioxide | epidermal growth factor receptor | Homo sapiens |
| 3 | As2O3 activates Src(Y416) whose activity (inhibited by PP2) modulates EGFR activation, its interaction with Shc/Grb2, and p-AKT. | Arsenic Trioxide | epidermal growth factor receptor | Homo sapiens |
| 4 | Collectively, As2O3 mediates an initial rise in pY-Src(416) to regulate the PI3K/AKT pathway which increases SnoN and cell survival; these early events may counter the cell death response associated with increased pY-EGFR/MAPK activation. | Arsenic Trioxide | epidermal growth factor receptor | Homo sapiens |