Title : Anti-inflammatory activity of anatabine via inhibition of STAT3 phosphorylation.

Pub. Date : 2013 Jan 5

PMID : 23178521






2 Functional Relationships(s)
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1 We observed that anatabine reduces pro-inflammatory cytokine production (IL-6, IL-1beta and TNF-alpha) in the plasma, kidney and spleen of the animals following the injection of LPS and concomitantly opposes STAT3 phosphorylation induced by LPS in the spleen and kidney. anatabine tumor necrosis factor Mus musculus
2 Following a chronic oral treatment with anatabine, a reduction in brain TNF-alpha and IL-6 levels compared to untreated Tg APPsw mice was observed. anatabine tumor necrosis factor Mus musculus