Title : Oxidative stress plays a major role in chlorpromazine-induced cholestasis in human HepaRG cells.

Pub. Date : 2013 Apr

PMID : 23175273






1 Functional Relationships(s)
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1 Compared to CPZ effects, overloading of HepaRG cells with high concentrations of cholic and chenodeoxycholic acids induced a delayed oxidative stress and, similarly, after 24 hours it down-regulated BSEP and MDR3 in parallel to a decrease of NTCP and CYP8B1 and an increase of MRP4. Cholic ATP binding cassette subfamily C member 4 Homo sapiens