Title : Chlorogenic acid attenuates high mobility group box 1 (HMGB1) and enhances host defense mechanisms in murine sepsis.

Pub. Date : 2013 Jan 22

PMID : 23168580






1 Functional Relationships(s)
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1 The mechanisms of action of chlorogenic acid included attenuation of the increase in toll-like receptor (TLR)-4 expression and suppression of sepsis-induced signaling pathways, such as c-Jun NH2-terminal kinase (JNK), p38 mitogen-activated protein kinase (MAPK) and nuclear factor (NF)-kappaB, which are critical for cytokine release. Chlorogenic Acid nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus