Pub. Date : 2012
PMID : 23166623
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Involvement of dynamin-related protein 1 in free fatty acid-induced INS-1-derived cell apoptosis. | Fatty Acids, Nonesterified | insulin 1 | Rattus norvegicus |
| 2 | Induction of DRP-1 expression significantly promoted FFA-induced apoptosis in DRP-1 WT (DRP-1 wild type) inducible INS-1-derived cell line, but not in DRP-1K38A (a dominant negative mutant of DRP-1) inducible INS-1-derived cell line. | Fatty Acids, Nonesterified | insulin 1 | Rattus norvegicus |
| 3 | Induction of DRP-1 expression significantly promoted FFA-induced apoptosis in DRP-1 WT (DRP-1 wild type) inducible INS-1-derived cell line, but not in DRP-1K38A (a dominant negative mutant of DRP-1) inducible INS-1-derived cell line. | Fatty Acids, Nonesterified | insulin 1 | Rattus norvegicus |
| 4 | These results indicated that DRP-1 mediates FFA-induced INS-1-derived cell apoptosis, suggesting that suppression of DRP-1 is a potentially useful therapeutic strategy for protecting against beta cell loss that leads to type 2 diabetes. | Fatty Acids, Nonesterified | insulin 1 | Rattus norvegicus |