PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 23166623-0 2012 Involvement of dynamin-related protein 1 in free fatty acid-induced INS-1-derived cell apoptosis. Fatty Acids, Nonesterified 44-59 insulin 1 Rattus norvegicus 68-73 23166623-7 2012 Induction of DRP-1 expression significantly promoted FFA-induced apoptosis in DRP-1 WT (DRP-1 wild type) inducible INS-1-derived cell line, but not in DRP-1K38A (a dominant negative mutant of DRP-1) inducible INS-1-derived cell line. Fatty Acids, Nonesterified 53-56 insulin 1 Rattus norvegicus 115-120 23166623-7 2012 Induction of DRP-1 expression significantly promoted FFA-induced apoptosis in DRP-1 WT (DRP-1 wild type) inducible INS-1-derived cell line, but not in DRP-1K38A (a dominant negative mutant of DRP-1) inducible INS-1-derived cell line. Fatty Acids, Nonesterified 53-56 insulin 1 Rattus norvegicus 209-214 23166623-12 2012 These results indicated that DRP-1 mediates FFA-induced INS-1-derived cell apoptosis, suggesting that suppression of DRP-1 is a potentially useful therapeutic strategy for protecting against beta cell loss that leads to type 2 diabetes. Fatty Acids, Nonesterified 44-47 insulin 1 Rattus norvegicus 56-61