Title : Dietary β-carotene regulates interleukin-1β-induced expression of apolipoprotein E in astrocytes isolated from stroke-prone spontaneously hypertensive rats.

Pub. Date : 2013 Jan

PMID : 23147682






4 Functional Relationships(s)
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1 Dietary beta-carotene regulates interleukin-1beta-induced expression of apolipoprotein E in astrocytes isolated from stroke-prone spontaneously hypertensive rats. beta Carotene apolipoprotein E Rattus norvegicus
2 Thus, we investigated the expression of apoE in primary astrocytes that had been treated with IL-1beta or beta-carotene. beta Carotene apolipoprotein E Rattus norvegicus
3 Conversely, beta-carotene significantly enhanced the expression levels of genes related to cholesterol regulation, including Abca1, Abcg1, Hmgcr as well as Apoe. beta Carotene apolipoprotein E Rattus norvegicus
4 These results suggest that IL-1beta decreases Apoe expression levels, whereas beta-carotene strongly elevates Apoe levels and inhibits FGF1-mediated gliosis of astrocytes. beta Carotene apolipoprotein E Rattus norvegicus