Title : Differential regulation of nuclear factor-kappa B subunits on epidermal keratinocytes by ultraviolet B and tacrolimus.

Pub. Date : 2012 Nov

PMID : 23140765






4 Functional Relationships(s)
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Protein Name
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1 Differential regulation of nuclear factor-kappa B subunits on epidermal keratinocytes by ultraviolet B and tacrolimus. Tacrolimus nuclear factor kappa B subunit 1 Homo sapiens
2 Recently, we have shown that direct regulation of NF-kappaB/p65 subunit may account for tacrolimus ointment"s remarkable clinical efficacy on treating inflammatory dermatoses. Tacrolimus nuclear factor kappa B subunit 1 Homo sapiens
3 Furthermore, treatment with tacrolimus didn"t affect the nuclear activation and translocation of NF-kappaB/p50, while the UVB induced NF-kappaB/p65 nuclear expression was suppressed by tacrolimus. Tacrolimus nuclear factor kappa B subunit 1 Homo sapiens
4 The clinical efficacy of tacrolimus may be attributed to its specific regulatory effect on NF-kappaB/p65 but not NF-kappaB/p50 of the NF-kappaB pathway. Tacrolimus nuclear factor kappa B subunit 1 Homo sapiens