Title : Ceramides contained in LDL are elevated in type 2 diabetes and promote inflammation and skeletal muscle insulin resistance.

Pub. Date : 2013 Feb

PMID : 23139352






3 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Here, we explored the role of circulating ceramide on the pathogenesis of insulin resistance. Ceramides insulin Homo sapiens
2 Ceramide transported in LDL is elevated in the plasma of obese patients with type 2 diabetes and correlated with insulin resistance but not with the degree of obesity. Ceramides insulin Homo sapiens
3 Treating cultured myotubes with LDL containing ceramide promoted ceramide accrual in cells and was accompanied by reduced insulin-stimulated glucose uptake, Akt phosphorylation, and GLUT4 translocation compared with LDL deficient in ceramide. Ceramides insulin Homo sapiens