Title : UCP2 inhibition triggers ROS-dependent nuclear translocation of GAPDH and autophagic cell death in pancreatic adenocarcinoma cells.

Pub. Date : 2013 Mar

PMID : 23124112






2 Functional Relationships(s)
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1 UCP2 inhibition triggers ROS-dependent nuclear translocation of GAPDH and autophagic cell death in pancreatic adenocarcinoma cells. Reactive Oxygen Species glyceraldehyde-3-phosphate dehydrogenase Homo sapiens
2 We also show that UCP2 inhibition triggers ROS-dependent nuclear translocation of the glycolytic enzyme glyceraldehyde 3-phosphate dehydrogenase (GAPDH), formation of autophagosomes, and the expression of the autophagy marker LC3-II. Reactive Oxygen Species glyceraldehyde-3-phosphate dehydrogenase Homo sapiens