Title : Regulation of interleukin-1 synthesis by histamine produced by mouse peritoneal macrophages per se.

Pub. Date : 1990 Jan

PMID : 2312155






4 Functional Relationships(s)
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1 IL-1 production was significantly blocked by either an H1 anti-histamine, diphenhydramine, or H2 anti-histamine ranitidine, in the absence of any exogenous histamine. Histamine interleukin 1 complex Mus musculus
2 IL-1 production was significantly blocked by either an H1 anti-histamine, diphenhydramine, or H2 anti-histamine ranitidine, in the absence of any exogenous histamine. Histamine interleukin 1 complex Mus musculus
3 Addition of exogenous histamine accentuated the IL-1 production by macrophages as a function of its dose. Histamine interleukin 1 complex Mus musculus
4 These results suggest that IL-1 production by mouse peritoneal macrophages is regulated by histamine synthesized in the system per se and that the effect of histamine is dependent on both H1 and H2 histamine receptors located on the surface of the cells. Histamine interleukin 1 complex Mus musculus