PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
2312155-4	1990	IL-1 production was significantly blocked by either an H1 anti-histamine, diphenhydramine, or H2 anti-histamine ranitidine, in the absence of any exogenous histamine.	Histamine	63-72	interleukin 1 complex	Mus musculus	0-4	
2312155-4	1990	IL-1 production was significantly blocked by either an H1 anti-histamine, diphenhydramine, or H2 anti-histamine ranitidine, in the absence of any exogenous histamine.	Histamine	102-111	interleukin 1 complex	Mus musculus	0-4	
2312155-5	1990	Addition of exogenous histamine accentuated the IL-1 production by macrophages as a function of its dose.	Histamine	22-31	interleukin 1 complex	Mus musculus	48-52	
2312155-6	1990	These results suggest that IL-1 production by mouse peritoneal macrophages is regulated by histamine synthesized in the system per se and that the effect of histamine is dependent on both H1 and H2 histamine receptors located on the surface of the cells.	Histamine	91-100	interleukin 1 complex	Mus musculus	27-31