Title : C5aR and C3aR antagonists each inhibit diet-induced obesity, metabolic dysfunction, and adipocyte and macrophage signaling.

Pub. Date : 2013 Feb

PMID : 23118029






1 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 In vitro C5a and C3a (100 nM) exhibited novel insulin-like effects on 3T3-L1 adipocytes, promoting energy conservation by increasing glucose and fatty acid uptake while inhibiting cAMP signaling and lipolysis, and induced PGE(2) release from macrophages, effects all blocked by each respective antagonist (10 muM). Prostaglandins E insulin Homo sapiens