Title : Exploring the PDE5 H-pocket by ensemble docking and structure-based design and synthesis of novel β-carboline derivatives.

Pub. Date : 2012 Nov

PMID : 23117589






1 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Some compounds were as active as tadalafil in inhibiting PDE5 and of better selectivity profile particularly versus PDE11A, the nature of the terminal ring and its nitrogen substituent are the main determinants of selectivity. Tadalafil phosphodiesterase 5A Homo sapiens