Title : Melatonin inhibits nitric oxide signaling by increasing PDE5 phosphorylation in coronary arteries.

Pub. Date : 2012 Dec 15

PMID : 23086989






1 Functional Relationships(s)
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1 Treatment of coronary arteries with melatonin caused a nearly fourfold increase in the phosphorylation of PDE5, which increased the catalytic activity of the enzyme and thereby increased the degradation of cGMP to inactive 5"-GMP. Guanosine Monophosphate phosphodiesterase 5A Homo sapiens