Pub. Date : 2012 Dec
PMID : 23064123
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | A series of C7-substituted chromone (1-benzopyran-4-one) derivatives were synthesized and evaluated as inhibitors of recombinant human monoamine oxidase (MAO) A and B. | Chromones | monoamine oxidase A | Homo sapiens |
| 2 | While the chromone derivatives also exhibit affinities for MAO-A, with IC(50) values ranging from 0.495 to 8.03 muM, they are selective for the MAO-B isoform. | Chromones | monoamine oxidase A | Homo sapiens |
| 3 | With the aid of modeling studies, potential binding orientations and interactions of selected chromone derivatives in the MAO-A and -B active sites are examined. | Chromones | monoamine oxidase A | Homo sapiens |