Title : Consecutive positive feedback loops create a bistable switch that controls preadipocyte-to-adipocyte conversion.

Pub. Date : 2012 Oct 25

PMID : 23063366






1 Functional Relationships(s)
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1 Conversion begins by glucocorticoid and cAMP signals raising C/EBPbeta levels above a critical threshold, triggering three consecutive positive feedback loops: from PPARgamma to C/EBPalpha, then to C/EBPbeta, and last to the insulin receptor. Cyclic AMP insulin receptor Homo sapiens