Pub. Date : 2012
PMID : 23056499
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | AZD1480 blocks growth and tumorigenesis of RET- activated thyroid cancer cell lines. | AZD 1480 | ret proto-oncogene | Homo sapiens |
| 2 | Here, we tested the efficacy of a JAK1/2- inhibitor, AZD1480, in the in vitro and in vivo growth of thyroid cancer cell lines expressing oncogenic RET. | AZD 1480 | ret proto-oncogene | Homo sapiens |
| 3 | In conclusion, AZD1480 effectively blocks proliferation and tumor growth of activated RET- thyroid cancer cell lines, likely through direct RET inhibition in cancer cells as well as by modulation of the microenvironment (e.g. via JAK/phospho-STAT3 inhibition in endothelial cells). | AZD 1480 | ret proto-oncogene | Homo sapiens |
| 4 | In conclusion, AZD1480 effectively blocks proliferation and tumor growth of activated RET- thyroid cancer cell lines, likely through direct RET inhibition in cancer cells as well as by modulation of the microenvironment (e.g. via JAK/phospho-STAT3 inhibition in endothelial cells). | AZD 1480 | ret proto-oncogene | Homo sapiens |
| 5 | Thus, AZD1480 should be considered as a therapeutic agent for the treatment of RET- activated thyroid cancers. | AZD 1480 | ret proto-oncogene | Homo sapiens |