Title : Methionine sulfoximine reduces cortical infarct size in rats after middle cerebral artery occlusion.

Pub. Date : 1990 Feb

PMID : 2305410






2 Functional Relationships(s)
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1 This protective effect may be mediated by a presynaptic mechanism; methionine sulfoximine profoundly inhibits brain glutamine synthetase, thereby interrupting the astrocyte-neuron glutamate shuttle and impairing neuronal glutamate release. Glutamic Acid glutamate-ammonia ligase Rattus norvegicus
2 This protective effect may be mediated by a presynaptic mechanism; methionine sulfoximine profoundly inhibits brain glutamine synthetase, thereby interrupting the astrocyte-neuron glutamate shuttle and impairing neuronal glutamate release. Glutamic Acid glutamate-ammonia ligase Rattus norvegicus