Pub. Date : 2013 Apr
PMID : 23053727
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Neferine inhibits the upregulation of CCL5 and CCR5 in vascular endothelial cells during chronic high glucose treatment. | neferine | C-C motif chemokine receptor 5 | Homo sapiens |
| 2 | The increased level of ROS and elevated expressions of CCL5 and CCR5 at high glucose were significantly inhibited by neferine; meanwhile the decreased NO production upon chronic high glucose treatment was relieved. | neferine | C-C motif chemokine receptor 5 | Homo sapiens |
| 3 | These data indicate that neferine can reduce the upregulation of CCL5 and CCR5 of vascular endothelium exposure to chronic high glucose and prevent or inhibit subsequent occurrence of inflammation in blood vessels possibly through antioxidation. | neferine | C-C motif chemokine receptor 5 | Homo sapiens |